We are investigating how mammalian cells process information about intra- and extracellular cues through their intra-cellular signalling and gene-regulatory networks, how these networks dysfunction in disease and how these networks can be modulated by drugs. We are an interdisciplinary team of experimentalists and theoreticians and utilise mathematical models and theoretical concepts as well as quantitative and high throuput experimental approaches to analyse signalling and gene expression.
We use methods from mathematical modeling, bioinformatics and quantitative cell biology to investigate how structure and dynamics of networks relate to their biological function. Our main focus is on oncogenic signaling pathways and their downstream gene regulatory networks mediate their oncogenic potential and the dynamics of differentiation processes.
Read more...We are an interdisciplinary team of experimentalists and theoreticians and use mathematical models and theoretical concepts as well as quantitative and high throuput experimental approaches to analyse signalling and gene expression.
Read more...