Abstract

The RAF-MEK-ERK cascade is one of the most investigated signaling pathways as it controls numerous vital cellular programs. There has been an immense amount of effort to determine and verify ERK target proteins which regulate these programs. With the rise of targeted phospho-proteomic technologies, the repository of ERK target proteins is profoundly expanding and the databases that maintain target phosphorylation information serve as great resources for researchers working in the field. However, compiling a comprehensive ERK target phospho-site archive is a predicament. Here, we gathered information from various research studies and a database to form a searchable compendium of ERK targets.